2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-E70624
    Thiamine pyrophosphate tetrahydrate 98%
    Thiamine pyrophosphate tetrahydrate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate tetrahydrate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases.
    Thiamine pyrophosphate tetrahydrate
  • HY-E70729
    ICK Recombinant Human Active Protein Kinase
    The intestinal cell kinase (ICK) protein belongs to the ros-cross hybridizing kinase (RCK) family. ICK is a ciliary protein, involved in ciliogenesis and regulation of intraflagellar transport (IFT). ICK Recombinant Human Active Protein Kinase is a recombinant ICK protein that can be used to study ICK-related functions.
    ICK Recombinant Human Active Protein Kinase
  • HY-E70730
    INSR Recombinant Human Active Protein Kinase
    The whole IGF axis constitutes an interactive network composed of the peptide-ligands IGF1, IGF2 and insulin, and the receptors IGF1R, IGF2R and insulin receptor (INSR) as IGF binding proteins (IGFBPs). The INSR itself appears in two isoforms, INSRA and INSRB differing in 12 amino acids encoded by exon 11. INSR Recombinant Human Active Protein Kinase is a recombinant INSR protein that can be used to study INSR-related functions.
    INSR Recombinant Human Active Protein Kinase
  • HY-E70832
    IRR Recombinant Human Active Protein Kinase
    IRR is a member of the insulin receptor (IR) family. IRR activation by alkali is determined by its N-terminal extracellular region. IRR Recombinant Human Active Protein Kinase is a recombinant IRR protein that can be used to study IRR-related functions.
    IRR Recombinant Human Active Protein Kinase
  • HY-E70864
    STK33 Recombinant Human Active Protein Kinase
    STK33 is clearly related to the canonical kinases from the CAMK group. STK33 could be involved in the normal development of heart and other organs in embryonic and fetal stages. STK33 Recombinant Human Active Protein Kinase is a recombinant STK33 protein that can be used to study STK33-related functions.
    STK33 Recombinant Human Active Protein Kinase
  • HY-E70867
    TGFβR2 Recombinant Human Active Protein Kinase
    TGF-β is a pleiotropic multifunctional cytokine that regulates many cellular processes, such as cell growth, differentiation, apoptosis and cellular homeostasis. Before exerting the biological effects within cells, TGF-β first requires extracellular activation, namely binds to its type II receptor (TGFβR2) and promotes the phosphorylation. TGFβR1 plays an important role in TGF-β signaling transduction and serves as a tumor suppressor. TGFβR2 Recombinant Human Active Protein Kinase is a recombinant TGFβR2 protein that can be used to study TGFβR2-related functions.
    TGFβR2 Recombinant Human Active Protein Kinase
  • HY-E70890
    β-Galactosidase Mutein, E. coli
    β-Galactosidase Mutein, E. coli is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.
    β-Galactosidase Mutein, E. coli
  • HY-E70891
    β-Galactose Dehydrogenase S, Pseudomonas fluorescens
    β-Galactose Dehydrogenase S, Pseudomonas fluorescens (EC 1.1.1.48) belongs to the oxidoreductase family and is an oxidoreductase that acts on the CH-OH group as a donor and uses NAD+ or NADP+ as an acceptor. β-Galactose Dehydrogenase S, Pseudomonas fluorescens, is involved in galactose metabolism. The enzyme's two substrates are D-galactose and NAD+, while its three products are D-galactonide-1,4-lactone, NADH, and H+.
    β-Galactose Dehydrogenase S, Pseudomonas fluorescens
  • HY-E70892
    β-D-Glucuronidase, Bacteria
    β-D-Glucuronidase, Bacteria (EC 3.2.1.31) catalyzes the breakdown of complex carbohydrates. β-D-Glucuronidase, Bacteria (EC 3.2.1.31) converts conjugated bilirubin into the unconjugated form, making bilirubin suitable for reabsorption.
    β-D-Glucuronidase, Bacteria
  • HY-E70893
    α-Lytic Protease M190A Mutant
    α-Lytic Protease is an alternative specificity protease for proteomics applications, whose wild-type (WT) version cleaves after T, A, S, and V residues. α-Lytic Protease M190A Mutant has different cleavage specificities, and cleaves after M, F, and L residues. Both the WT and M190A forms of aLP geneRate peptides of similar average length as trypsin.
    α-Lytic Protease M190A Mutant
  • HY-E70894
    α,γ-Homocysteinase, Trichomonas vaginalis
    α,γ-Homocysteinase, Trichomonas vaginalis is a pyridoxal-5’-phosphate dependent enzyme. α,γ-Homocysteinase, Trichomonas vaginalis is a mutant of homocysteinase from Trichomonas vaginalis encoded by mgl1 gene, containing three point mutations, such as; Phe47Leu, Asp172Glu, Ser308Tyr. α,γ-Homocysteinase, Trichomonas vaginalis can metabolize homocysteine into α-keto butyrate, hydrogen sulfide and ammonia.
    α,γ-Homocysteinase, Trichomonas vaginalis
  • HY-E70895
    α2-3 Neuraminidase S, Streptococcus pneumoniae
    α2-3 Neuraminidase S, Streptococcus pneumoniae is a glycoside hydrolase enzyme that cleave the glycosidic linkages of neuraminic acids.
    α2-3 Neuraminidase S, Streptococcus pneumoniae
  • HY-E70896
    Xyloglucanase, Clostridium thermocellum
    Xyloglucanase, Clostridium thermocellum (EC 3.2.1.151) belongs to the hydrolase family and is a glycosidase that hydrolyzes O- and S-glycosidic compounds. The two substrates of Xyloglucanase, Clostridium thermocellum are xyloglucan and water, and its product is a xyloglucan oligosaccharide.
    Xyloglucanase, Clostridium thermocellum
  • HY-E70897
    Xylanase 10A, Cellvibrio japonicus
    Xylanase 10A, Cellvibrio japonicus (EC 3.2.1.8) is the name given to a class of enzymes which degrade the linear polysaccharide beta-1,4-xylan into xylose, thus breaking down hemicellulose, one of the major components of plant cell walls.
    Xylanase 10A, Cellvibrio japonicus
  • HY-E70898
    Trehalose-6-phosphate hydrolase, Escherichia coli
    Trehalose-6-phosphate hydrolase, Escherichia coli (EC 3.2.1.93), belongs to the hydrolase family and is a glycosidase that hydrolyzes O- and S-glycoside compounds. Trehalose-6-phosphate hydrolase participates in the metabolism of starch and sucrose. Its substrates are α,α'-trehalose-6-phosphate and water, and its products are D-glucose and D-glucose-6-phosphate.
    Trehalose-6-phosphate hydrolase, Escherichia coli
  • HY-E70899
    Topoisomerase IV, Streptococcus pneumoniae
    Topoisomerase IV, Streptococcus pneumoniae (EC 5.99.1.) is prepared by overexpressing the subunits in E. coli.
    Topoisomerase IV, Streptococcus pneumoniae
  • HY-E70900
    Topoisomerase II β, Human
    Topoisomerase II β, Human (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
    Topoisomerase II β, Human
  • HY-E70901
    Topoisomerase II α, Human
    Topoisomerase II α, Human (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
    Topoisomerase II α, Human
  • HY-E70902
    Topoisomerase II, Yeast
    Topoisomerase II, Yeast (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
    Topoisomerase II, Yeast
  • HY-E70903
    Thermitase, Bacillus cereus
    Thermitase, Bacillus cereus is a protease that inactivates Rnases, Dnases and enzymes in reactions.
    Thermitase, Bacillus cereus
Cat. No. Product Name / Synonyms Application Reactivity